Neuregulin 2 Antikörper (Middle Region)

Produktnummer ABIN3031975

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Neuregulin 2 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für Neuregulin 2 Antikörper (Middle Region) (ABIN3031975)

Target: Neuregulin 2 (NRG2)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Neuregulin 2 Antikörper

Bindungsspezifität: Middle Region

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human NRG2 (NGRKNSRLQFNKVKVEDA) was used as the immunogen for this NRG2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the NRG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the NRG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Neuregulin 2

Target: Neuregulin 2 (NRG2)

Andere Bezeichnung: NRG2

Hintergrund: Neuregulin 2, also known as DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 is a member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The genomic structure is similar to that of neuregulin 1(NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

UniProt: O14511

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung